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IsoTis OrthoBiologics

IsoTis Completes Transfer of PolyActive IP Estate to OctoPlus

Irvine, California (ots/PRNewswire)

IsoTis, Inc. (NASDAQ: ISOT),
the orthobiologics company, today  announced it has completed the
transfer of the rights associated with its  PolyActive technology to
OctoPlus (Euronext: OCTO), a drug delivery and  development company,
in exchange for an up-front payment of approximately  $1.7 million
and future royalty payments on sales of pharmaceutical products
based on the PolyActive technology.
Under the agreement, IsoTis retains the rights to manufacture,
market, and sell orthopedic plugs and cement restrictors including
those related to its marketed product SynPlug(R), based on the
PolyActive technology.
About IsoTis, Inc.
IsoTis is a leading orthobiologics company that develops,
manufactures and markets proprietary products for the treatment of
musculoskeletal diseases and disorders. IsoTis' current
orthobiologics products are bone graft substitutes that promote the
regeneration of bone and are used to repair natural, trauma-related
and surgically-created defects common in orthopedic procedures,
including spinal fusions. IsoTis' current commercial business is
highlighted by its Accell line of products, which the company
believes represents the next generation in bone graft substitution.
About OctoPlus
OctoPlus N.V. is a product-oriented biopharmaceutical company
committed to the development of improved pharmaceutical products that
are based on its proprietary drug delivery technologies and have
fewer side effects, improved patient convenience and a better
efficacy/safety balance than existing therapies. Rather than seeking
to discover novel drug candidates through early stage research
activities, OctoPlus focuses on the development of long-acting,
controlled release versions of known protein therapeutics and other
drugs.
OctoPlus is also a leading provider of advanced drug formulation
and clinical scale manufacturing services to the pharmaceutical and
biotechnology industry, with a focus on difficult to formulate active
pharmaceutical ingredients in injectable formulations. The earnings
and expertise that OctoPlus derives from rendering formulation and
manufacturing services help to support its own drug development
programs.
Certain statements in this press release are "forward-looking
statements" within the meaning of Section 21E of the Securities
Exchange Act of 1934, as amended, including those that refer to
management's plans and expectations for future operations, prospects
and financial condition. Words such as "strategy," "expects,"
"plans," "anticipates," "believes," "will," "continues," "estimates,"
"intends," "projects," "goals," "targets" and other words of similar
meaning are intended to identify such forward-looking statements. One
can also identify them by the fact that they do not relate strictly
to historical or current facts. Such statements are based on the
current expectations of the management of IsoTis only. Undue reliance
should not be placed on these statements because, by their nature,
they are subject to known and unknown risks and can be affected by
factors that are beyond the control of IsoTis. Actual results could
differ materially from current expectations due to a number of
factors and uncertainties affecting IsoTis' business, including, but
not limited to, a competitive sales and marketing environment, the
timely commencement and success of IsoTis' clinical trials and
research endeavors, delays in receiving U.S. Food and Drug
Administration or other regulatory approvals (a.o. EMEA, CE),
including the risk that the FDA determines that our Accell Putty and
Accell TBM products are not human tissue or class II medical devices,
that the Company is unable to obtain 510(k) clearance for its Accell
products, that the FDA requires the Company to obtain premarket
approval of its Accell products prior to continuing their marketing,
that the FDA requires the Company to produce additional clinical data
to support approval or clearance of its products, that the FDA
imposes compliance measures against the Company for the marketing of
its Accell products, including imposing fines and injunctions or
causing the Company to recall its Accell products, market acceptance
of IsoTis' products, effectiveness of IsoTis' distribution channels,
development of competing therapies and/or technologies, the terms of
any future strategic alliances, the need for additional capital, the
inability to obtain, or meet, conditions imposed for required
governmental and regulatory approvals and consents. IsoTis expressly
disclaims any intent or obligation to update these forward-looking
statements except as required by law. For a more detailed description
of the risk factors and uncertainties affecting IsoTis, refer to the
Annual Report on Form 20-F for the fiscal year ended December 31,
2005 of IsoTis SA, the predecessor of the Company, filed with the
SEC, to IsoTis SA's reports filed from time to time with the Swiss
Stock Exchange (SWX), Euronext Amsterdam N.V., SEDAR at www.sedar.com
and the Toronto Stock Exchange (TSX), and to the reports filed from
time to time by the Company with the SEC.

Contact:

For information contact: Rob Morocco, CFO, +1-949-855-7155,
robert.morocco@isotis.com; Hans Herklots, Director IR,
+1-949-855-7195 or +41-(21)-620-6011, hans.herklots@isotis.com

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