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Tipranavir's EU Approval Provides a New Active Drug to be Combined with FUZEON(R) for HIV Patients Facing Resistance

Basel, Switzerland (ots/PRNewswire)

Following today's European
approval of Boehringer Ingelheim's boosted protease inhibitor
tipranavir (APTIVUS(R)), European patients now have the chance to
benefit from the potent combination of the fusion inhibitor FUZEON
(enfuvirtide) and boosted tipranavir in addition to their current
treatment regimen.
The clinical trials RESIST I and II showed that almost double the
proportion of patients who received FUZEON plus tipranavir/r showed a
90 percent drop in viral load compared with patients not receiving
FUZEON. This FUZEON effect was shown in other clinical trials
combining FUZEON with other boosted protease inhibitors, including
lopinavir/r and TMC 114/r.
The use of FUZEON with tipranavir for the management of
treatment-experienced patients was supported by recently updated
treatment guidelines by the Department of Health and Human Services
in the US, where tipranavir has been available to patients since June
2005. For the first time, the guidelines also recommended the
treatment goal of achieving suppression of the virus to levels that
make it undetectable in the blood for these patients.
Notes to Editors:
Growing Body of Evidence, RESIST 1&2 / POWER 1&2 / TORO 1&2 -
Collectively the data from all six studies, in over 2,500 patients,
establish a new paradigm in the management of triple
class-experienced patients.
RESIST Phase III tipranavir trials
- Over 24 weeks, almost double the proportion of patients who
received FUZEON plus boosted tipranavir showed a 90% drop in viral
load compared with patients not receiving FUZEON
POWER Phase II TMC114 dosing trials
  • Over 24 weeks in the combined TMC114 trials, almost double the proportion of patients who received FUZEON plus boosted TMC114 achieved a viral load below 50 copies/ml compared with patients not receiving FUZEON
  • A remarkable 67% of the patients receiving FUZEON plus boosted TMC114 reached an undetectable viral load
TORO Phase III FUZEON trials
- Over 24 weeks, double the proportion of patients who received
FUZEON plus boosted lopinavir achieved an undetectable viral load
(<50 copies/ml) compared with patients not receiving FUZEON
Recommendations - The updated DHHS guidelines (October 6,
2005) are available online: http://aidsinfo.nih.gov/guidelines/.
The Panel on Clinical Practices for Treatment of HIV Infection of
the US Department of Health and Human Services (DHHS) focuses on the
overall management of treatment-experienced patients. It also
provides guidance on changing an antiretroviral therapy regimen for
virologic failure, for which the latest recommendations include:
  • Using the treatment history and past and current resistance test results to identify active agents (preferably at least two fully active agents) to design the new regimen. A fully active agent is one likely to demonstrate antiretroviral activity on the basis of both the treatment history and susceptibility on drug-resistance testing.
  • Adding a drug with activity against drug-resistant virus (e.g. a potent ritonavir-boosted PI) and a drug with new mechanism of action (e.g. HIV entry inhibitor) to an optimised background antiretroviral regimen can provide significant antiretroviral activity.
The boosting of PIs is a therapeutic strategy wherein a small dose
of ritonavir is given concurrently with another PI to
pharmacologically enhance exposure to the latter PI through the
inhibition of the enzyme cytochrome p450. Ritonavir boosting results
in increased drug levels that can increase efficacy, decrease pill
burden, add flexibility to the dosing schedule, and remove fasting
restrictions. To indicate a PI has been boosted with ritonavir, the
sign "/r is included after the PI's name.
All trademarks used or mentioned in this release are legally
protected.

Contact:

For more information, please contact: Laura Bertossi, Ketchum,
Office: +44-207-611-3597 E-Mail: laura.bertossi@ketchum.com Janet
Sanburg, F. Hoffmann-La Roche Ltd, Mobile: +41-79-255-9414 Email:
janet.sanburg@roche.com

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