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European Society for Medical Oncology (ESMO)

35th ESMO Congress: Milan, Italy (FieraMilanoCity), 8-12 October 2010 - Press Programm CURTAIN RAISER

Lugano (ots)

Press releases will be issued during the Congress,
on a daily basis.
Please contact the ESMO Press Office at  media@esmo.org if you 
would like to receive the full text of the press releases/abstracts 
in advance, available as of Wednesday, 6 October 2010
R. Bastian, DE
Surgical technique relieves painful spine fractures in patients 
with metastatic cancer (embargo: 9 October, 9:00 Milan time)
Many patients with multiple myeloma, or those whose cancer has 
spread beyond the initial tumor site, suffer compression fractures in
their spine. A surgical technique appears to offer quick and 
effective relief for debilitating spinal fractures often suffered by 
these patients.
D. Spigel, DE
New targeted therapy adds benefit to erlotinib in some patients 
with advanced lung cancer (embargo: 9 October, 11:00 Milan time)
A subset of lung cancer patients seem to live longer and 
experience delays in disease progression when a new drug that targets
a cancer- associated molecule is added to treatment with erlotinib.
C. Zhou, CN
Erlotinib improves progression-free survival as first-line therapy
in advanced lung cancer: Phase-III data (embargo: 9 October, 11:00 
Milan time)
For patients with advanced lung cancer whose tumors carry EGFR 
activating mutations, first-line treatment with erlotinib nearly 
tripled progression-free survival compared to a standard chemotherapy
combination.
Y.T. MA, UK
Study reveals cancer-linked epigenetic effects of smoking 
(embargo: 9 October, 13:00 Milan time)
For the first time, scientists have reported direct evidence that 
taking up smoking results in epigenetic changes associated with the 
development of cancer.
U. Matulonis, US
Investigational ovarian cancer drug shows promise against 
platinum- resistant disease in Phase-II study (embargo: 9 October, 
13:00 Milan time)
A drug being developed as a treatment for ovarian cancer has shown
single agent activity with durable disease control in some patients 
in a Phase-II clinical trial.
G. Long, AU
Melanoma drug shrinks brain metastases in Phase-I/II study 
(embargo: 10 October, 11:00 Milan time)
A new drug being developed to treat potentially deadly melanoma 
skin cancers has shown a promising ability to shrink secondary 
tumors, known as metastases, in the brain in patients with advanced 
forms of the disease.
A. Palumbo, IT
High response rate seen in Phase-III trial of chemotherapy, new 
drug and stem cells in myeloma (embargo: 10 October, 12:30 Milan 
time)
The first study of its kind comparing two different approaches to 
treating newly diagnosed multiple myeloma has found that both 
treatments achieved a positive response.
M. Clavarezza, IT
Most Italian breast cancer patients older, and diagnosed very 
early (embargo: 10 October, 12:30 Milan time)
A study of breast cancer in Italian women has found that more than
70% of those affected by the disease are over the age of 50 years, 
and the disease is identified before it has spread to the lymph nodes
in more than 60% of cases.
H.A. Azim, BE
Study finds breast-feeding safe for women after breast cancer 
treatment (embargo: 10 October, 12:30 Milan time)
Women who have survived breast cancer should not be denied the 
opportunity to breast-feed their children. There is no evidence that 
breastfeeding is dangerous for mother or child after breast cancer 
treatment.
K.M. Tveit, NO
Cetuximab adds no benefit to chemotherapy in first-line treatment 
of metastatic colorectal cancer - New Phase-III data (embargo: 10 
October, 13:30 Milan time)
Adding the targeted drug cetuximab to a three-drug chemotherapy 
regimen for first-line treatment of metastatic colorectal cancer does
not improve response rate, progression-free survival or overall 
survival.
A. Gennari, IT
Prolonging first-line chemotherapy improves outcomes for patients 
with metastatic breast cancer (embargo: 10 October, 15:30 Milan time)
Patients with metastatic breast cancer live longer on average if 
their chemotherapy is continued after their cancer is brought under 
control, a new meta-analysis shows.
J. O'Shaughnessy, US
Iniparib extends overall survival in metastatic triple-negative 
breast cancer: final Phase-II results (embargo: 10 October, 15:30 
Milan time)
Women with an aggressive subtype of metastatic breast cancer 
appear to live longer when treated with iniparib plus chemotherapy, 
compared to chemotherapy alone, the results of a randomized Phase-II 
trial show.
M. Pavel, DE
Phase-III study shows everolimus delays tumor progression in 
hard-to-treat neuroendocrine tumors (embargo: 11 October, 10:30 Milan
time)
The results of a large Phase-III clinical trial have shown that 
the drug everolimus delays tumor progression in patients with a 
hard-to- treat group of rare cancers that affect particular 
hormone-producing cells.
B. Koczwara, AU
Fertility concerns of cancer survivors inadequately addressed, 
study finds (embargo: 11 October, 12:30 Milan time)
Many cancer survivors experience changes in sexual function that 
leave them feeling guilt and a longing for intimacy. The researchers 
say that these sexuality and fertility concerns are often not 
adequately addressed by doctors.
Y. Loriot, FR
Sexual issues a major concern for cancer patients taking new 
targeted drugs (embargo: 11 October, 12:30 Milan time)
New drugs that target specific molecular mechanisms of cancer have
improved the treatment of cancer patients in recent years, but those 
benefits may come with a cost to the patient's sex life, researchers 
have found.
B. You, FR
Early cancer drug trials flawed by inconsistencies in prohibited 
drug lists, study finds (embargo: 11 October, 12:30 Milan time)
Substantial inconsistencies in a basic aspect of the way Phase-I 
and Phase-II cancer clinical trials are designed. Researchers report 
finding unexpectedly large differences in the lists of drugs that 
trial designers say participants should not be given to avoid 
potentially dangerous drug-drug interactions.
T. Mok, CN
New Phase-II study shows first-line promise of lung cancer drug 
PF- 299 (embargo: 11 October, 13:15 Milan time)
A new-generation lung cancer drug has shown an impressive ability 
to prevent disease progression when administered as a first-line 
treatment in patients with advanced disease.
A. Necchi, IT
Pazopanib shows promise in Phase-II trial for relapsed/refractory 
urothelial cancer (embargo: 11 October, 13:30 Milan time)
An ongoing Phase-II trial investigating a new, targeted therapy 
for metastatic urothelial cancer has generated promising early 
results.
J. Vermorken, NL
Panitumumab fails to add overall survival benefit in 
recurrent/metastatic head and neck cancer: full Phase-III results 
(embargo: 11 October, 13:30 Milan time)
Adding the monoclonal anti-EGFR antibody panitumumab to 
chemotherapy did not significantly improve overall survival for 
patients with recurrent and/or metastatic head and neck cancer, 
according to Phase- III trial results.
J. Baselga, US
Adding cetuximab to chemotherapy doubles response rate in hard-to-
treat breast cancer (embargo: 11 October, 15:00 Milan time)
For the first time researchers have proven that targeting the 
epidermal growth factor receptor can provide substantial clinical 
benefit for women with hard-to-treat "triple negative" breast cancer.
E. Perez, US
New type of targeted therapy shows promise as first-line therapy 
for HER2-positive metastatic breast cancer (embargo: 11 October, 
15:00 Milan time)
A new type of breast cancer treatment has shown encouraging 
activity as a first-line therapy in HER2-positive metastatic disease.
J. De Bono, UK
Abiraterone acetate improves survival in metastatic castration- 
resistant prostate cancer: Phase-III results (embargo: 11 October, 
15:00 Milan time)
Patients with metastatic castration-resistant prostate cancer who 
have progressed after chemotherapy live significantly longer if 
treated with the drug abiraterone acetate compared to placebo, the 
results of a large Phase-III clinical trial confirm.
C.H. Yang, TW
Final results from landmark trial confirm survival benefits of 
EGFR mutations in lung cancer (embargo: 11 October, 15:00 Milan time)
Mature results from a landmark Phase-III trial have confirmed that
patients with EGFR mutation-positive advanced non-small cell lung 
cancer have better overall survival when treated with gefitinib or 
chemotherapy than patients whose tumors do not carry such mutations.
V. Miller, US
Afatinib benefits lung cancer patients whose cancer progressed 
after treatment with EGFR inhibitors (embargo: 11 October, 15:00 
Milan time)
Lung cancer patients who have already been treated with the EGFR 
inhibitors erlotinib or gefitinib seem to gain further benefits in 
terms of progression-free survival and tumor shrinkage when treated 
with the new drug afatinib, the results of a Phase-IIb/III trial 
show.
T. Perren, UK
Promising early results suggest bevacizumab adds survival benefit 
in newly diagnosed ovarian cancer (embargo: 11 October, 15:00 Milan 
time)
Early results from a large Phase-III trial suggest that adding 
bevacizumab to chemotherapy as a treatment for newly diagnosed 
ovarian cancer reduces the risk of disease progression during the 
first year of treatment.
Embargo Policy All information presented at the 35th ESMO Congress
is embargoed until the start of the session during which the abstract
is presented. Journalists are required to observe embargoes as 
indicated.
Appointments for media representatives Full details available at 
www.esmo.org/newsroom/events
Friday, 8 October 2010, 12:00-13:00
Opening Press Conference
Latest available data on the global cancer burden; main topics to 
be presented during the Congress, including the most recent advances 
in the treatment of cancer; Congress statistics and highlights for 
members of the media will be offered to attending journalists helping
them to make their way through what will be a very exciting meeting, 
thanks to a top-quality program.
  • Prof. David J. Kerr, ESMO President
  • Prof. Rolf A. Stahel, ESMO2010 Scientific Chair
  • Prof. Fortunato Ciardiello, ESMO2010 Press Officer
Saturday, 9 October 2010, 8:15-9:00
Press Briefing Day 1
Advanced breast cancer, Chest tumors, Palliative Care
Saturday, 9 October 2010, 12:00-12:45
Press Conference - The battle against rare cancers in Europe
More clinical trials for rare cancers are needed in Europe. 
Current lack of information, late diagnosis or misdiagnosis and 
practical obstacles to research, treatment and care will be 
discussed.
Sunday, 10 October 2010, 8:15-9:00
Press Briefing Day 2
Early and advanced breast cancer
Sunday, 10 October 2010, 12:15-13:00
Press Conference - Cancer patient long-term rehabilitation: body 
and beyond
Welfare and healthcare, public and private employment, equal 
treatment, communications and awareness will be discussed (at 
national and European level) to raise interest in cancer patient 
issues that are too often underestimated.
Monday, 11 October 2010, 8:15-9:00
Press Briefing Day 3
Advanced breast cancer, Chest tumors, Gynecological cancers, 
Genitourinary tumors
Tuesday, 12 October 2010, 8:15-9:00
Wrap-up
Your opportunity to ask any unanswered questions Closing comments 
by the President on the most important congress scientific 
presentations Updated event figures
General information
  • The full conference program is available at http://www.esmo.org/events/milan-2010-congress/program.html
  • All press events will be held in Room Asia, Press Center, Mezzanine Bridge but can be followed also remotely via toll-free dial-in:
  • Australia: 1/800-00-59-03
  • Belgium: 0800-39-244
  • Canada: 1/866-416-25-55
  • China North: 10/800-712-18-94
  • China South: 10/800-120-18-94
  • France: 0800/946-502
  • Italy: 800/136-706
  • Japan: 00531/12-12-66
  • Netherlands: 0800/949-45-17
  • Spain: 900/803-963
  • Switzerland: 800/24-67-87-00
  • UK: 800/3681-054
  • USA: 1/866-291-41-66
  • Other numbers available upon request
  • Interested journalists are kindly requested to notify us asap if they intend to use the remote dial-in
-You can contact the ESMO Press Office at  media@esmo.org to pre-  
book your interviews both in presence and remotely. Experts in       
various oncology fields will be available in the ESMO Media       
Ambassador Corner in the Press Center for interviews every day.
Media registration
On-site registration is possible at the Press Registration Desk. 
You will be asked for your press card and a letter of assignment.

Contact:

Vanessa Pavinato
Mobile: +41/79/935'60'73
E-Mail: media@esmo.org

Congress Press Office
Tel.: +39/02-4342-3649 (as of Thursday, 7 October)

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