Xetra (euro adhoc) -

  Notification concerning transactions by persons discharging managerial
  responsibilities pursuant to section 15a of the WpHG, transmitted by euro
  adhoc with the aim of a Europe-wide distribution. The issuer is responsible
  for the content of this announcement.

14.06.2007

Details of the person subject to the disclosure
requirement:

Name:              Hans Dieter Rössler
Name of contact/telephone number:
Kerstin Kornett
Vorstandsassistentin
Telefon: +49(0)6027 4686-431
E-Mail:  kerstin.kornett@curasan.de

Reason for the disclosure requirement:
Reason:            Person performing managerial responsibilities
Position:          Member of a managing body

Details of the transaction:
Description of financial instrument: Aktie

ISIN:                DE0005494538
Type of transaction: purchase
Date:                14.06.2007
No of items:         7000
Currency:            Euro
Price:               2.60000
Total amount traded: 18,200.00000
Place:               Xetra
Explanation:

Issuer subject to the publication requirement:

end of announcement                               euro adhoc 14.06.2007 14:32:23

Further inquiry note:

Kerstin Kornett
Vorstandsassistentin
Telefon: +49(0)6027 4686-431
E-Mail: kerstin.kornett@curasan.de

Branche: Biotechnology
ISIN: DE0005494538
WKN: 549453
Index: CDAX, Classic All Share, Prime All Share
Börsen: Frankfurter Wertpapierbörse / regulated dealing/prime
standard
Börse Berlin-Bremen / free trade
Hamburger Wertpapierbörse / free trade
Baden-Württembergische Wertpapierbörse / free trade
Börse Düsseldorf / free trade
Niedersächsische Börse zu Hannover / free trade
Bayerische Börse / free trade