OTC (euro adhoc) -

  Notification concerning transactions by persons discharging managerial
  responsibilities pursuant to section 15a of the WpHG, transmitted by euro
  adhoc with the aim of a Europe-wide distribution. The issuer is responsible
  for the content of this announcement.

09.07.2007

Details of the person subject to the disclosure requirement:

Name:              Dr. Heinz Fischer

Reason for the disclosure requirement:

Reason:            Person performing managerial responsibilities
Position:          Member of an administrative or supervisory body

Details of the transaction:
Description of financial instrument: ordinary bearer share

ISIN:                6637390
Type of transaction: sales
Date:                09.07.2007
No of items:         62000
Currency:            Euro
Price:               8.00000
Total amount traded: 496,000.00000
Place:               OTC
Explanation:         Sales in context of the mandatory offer

Issuer subject to the publication requirement:

end of announcement                               euro adhoc 11.07.2007 09:42:32

Further inquiry note:

Branche: Pharmaceuticals
ISIN: DE0006637390
WKN: 663739
Index: CDAX, Prime All Share, Technologie All Share
Börsen: Börse Frankfurt / regulated dealing/prime standard
Börse Berlin / free trade
Börse Hamburg / free trade
Börse Stuttgart / free trade
Börse Düsseldorf / free trade
Börse München / free trade