Epigenomics AG

EANS-News: Epigenomics AG: Surveys Show That Patients Believe in Blood Tests for Regular Colorectal Cancer Screening

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Subtitle: Results of a joint survey by Epigenomics AG and europacolon during the
first European Colorectal Cancer Patient Conference; nationwide survey in the
U.S. reports similar results 

Berlin, Germany, and Seattle, WA, U.S.A, July 7, 2011 (euro adhoc) - Epigenomics
AG (Frankfurt Prime Standard: ECX), the cancer molecular diagnostics company,
today announced the results of a survey conducted at europacolon´s first
European CRC Patient Conference, The Power of Patient Voice 2011, showing that
patients believe tests using blood samples would encourage more people to
participate in regular screening for colorectal cancer. 

Of the participants in the survey, more than 50% had previously heard of the
possibility of CRC blood testing and more than 70% thought that using a blood
test would encourage more people to participate in regular screening for
colorectal cancer. Some of the most often mentioned reasons that survey
participants gave for preferring blood tests were ease-of-use and simplicity,
not having to handle stool samples as necessary for conventional non-invasive
testing, and overall fit with other routine blood tests.

The survey was jointly conducted by Epigenomics and europacolon, the first
European non-profit organization dedicated to colorectal cancer. europacolon´s
mission is to prevent deaths from colorectal cancer and improve the quality of
life and support for those affected by the disease. Epigenomics has developed
the world´s first in vitro diagnostic blood test for the early detection of
colorectal cancer known as the Septin9 Test and fully supports europacolon in
its fight against colorectal cancer.

Jola Gore-Booth, the Founder and CEO of europacolon commented: "We are delighted
that over 140 delegates from 27 countries globally attended this first ever
Colorectal Cancer Patient Conference. The great success of the Conference has
given us enormous encouragement in our work to promote the prevention and early
diagnosis of colorectal cancer in all European countries. Putting in place
formal population screening programs for all the citizens of Europe is essential
for effective prevention of colorectal cancer and for saving thousands of lives.
A blood test for the early detection of colorectal cancer could remove some of
the hurdles to effective compliance to colorectal cancer screening and be
instrumental in reducing mortality from this killer disease."

Independent of the europacolon survey, Quest Diagnostics, one of Epigenomics´
partners in the U.S.A., in June announced, in collaboration with the U.S.
non-profit organization Colon Cancer Alliance, the results of a jointly
conducted U.S. national telephone survey of more than 1,300 men and women 50
years of age and older. In this survey, 31% of the participants reported that
they had never been screened for CRC. Of the respondents between 60-70 years of
age that had previously participated in screening, 33% stated that they had only
been screened once in the past. These results demonstrate widespread lack of
adherence to national guidelines in the U.S.A., which recommend regular
screening by colonoscopy in combination with other tests for colorectal cancer
for all men and women aged 50 and older. When asked about the option of a blood
test, 78% of the participants said that they were likely to take a blood test
for colorectal cancer screening and 75% said they were more likely to get
screened more frequently if a blood test was offered to them. The survey results
were presented during the Colon Cancer Alliance´s national conference "Family
Matters: What You and Your Family Need to Know about Colon Cancer," which was
held June 23-25 in Denver, CO, U.S.A.

Dr. Jürgen Beck, M.D., Senior VP Medical Affairs of Epigenomics, commented: "The
lack of widespread acceptance and regular utilization of conventional methods
for the early detection of colorectal cancer, such as colonoscopy and stool
tests, severely limit the potential of screening to reduce mortality from this
common cancer. The two surveys in Europe and the U.S.A. clearly show the
potential of blood-based screening as an approach to increase compliance. We
expect these findings to be substantiated further through studies into patient
preferences and screening adherence that are ongoing at clinical centers in the
U.S.A. and Europe."

Colorectal cancer is curable in more than 90% of cases if diagnosed while still
localized. Nevertheless, this disease is one of the most frequent causes of
cancer-related deaths in the industrialized world due to lack of adherence to
current screening recommendations.


Further information

For further information on europacolon please visit www.europacolon.com.
The 2011 europacolon Colorectal Cancer Patient Conference "The Power of Patient
Voice" was held on June 24-25, 2011 alongside the 13th World Congress on
Gastrointestinal Cancers organized by the European Society for Medical Oncology
in Barcelona, Spain.

For information on the Colon Cancer Alliance please see www.ccalliance.org.
For press releases on the U.S. survey, please visit Quest Diagnostics´ website
at http://questdiagnostics.mediaroom.com/index.php?s=43  
or the Colon Cancer Alliance website at 

About Epigenomics

Epigenomics (www.epigenomics.com) is a molecular diagnostics company developing
and commercializing a pipeline of proprietary products for cancer. The Company´s
products enable doctors to diagnose cancer earlier and more accurately, leading
to improved outcomes for patients. Epigenomics´ lead product, Epi proColon®, is
a blood-based test for the early detection of colorectal cancer, which is
currently marketed in Europe and is in development for the U.S.A. The Company´s
technology and products have been validated through multiple partnerships with
leading global diagnostic companies including Abbott, Quest Diagnostics, QIAGEN,
and Sysmex. Epigenomics is an international company with operations in Europe
and the U.S.A.

About europacolon

europacolon is an independent Not for Profit organisation founded in 2005. It is
the first European organisation dedicated to colorectal cancer and it aims to
unite patients, carers, healthcare professionals, politicians, the media and the
public in the fight against the disease. europacolon´s mission is to reduce
deaths and improve the quality of life and support for those affected by
colorectal cancer in Europe. 
Its aims and objectives are to:
- Prioritise and raise the profile of colorectal cancer
- Establish patient advocacy groups
- Create a colorectal cancer community
- Increase awareness of symptoms and prevention of the disease
- Campaign for screening and improved choice of treatments
- Encourage the improvement of European standards and equity of care through the
development of National Cancer Plans

Since 2005 europacolon has established dedicated colorectal cancer organisations
in 27 European countries: 10 Affiliate Members; 8 Associate Members; and 9
pending Members (Austria, Belgium, Bosnia and Herzegovina, Croatia, Cyprus,
Czech Republic, France, Finland, Germany, Georgia, Greece, Hungary, Italy,
Latvia, Lithuania, Netherlands, Republic of Macedonia, Poland, Portugal,
Romania, Russia, Serbia, Slovakia, Slovenia, Spain, Sweden, and the UK).

For more information, please visit www.europacolon.com 

Notes for editors

About Colorectal Cancer

For 2011 the American Cancer Society expects an estimated 140,000 new cases of
colorectal cancer to be diagnosed in the United States and almost 50,000 U.S.
citizens to die from the disease. The 5-year survival rate is over 90% if the
disease is treated in early stages but diminishes to about 12% once the cancer
has affected other organs. Today, the majority of cancers are still found in
advanced stages due to insufficient patient compliance to screening
recommendations that leaves half of the population unscreened. Increasing
compliance to regular cancer screening in the population aged 50 years and older
is considered key to decreasing mortality from this disease.

Septin9 blood tests for CRC

Epigenomics and its partner Abbott already market their respective first
generation CE-marked Septin9 tests in Europe, the Middle East, Asia/Pacific and
further markets. Epigenomics is in the process of developing a second generation
Septin9 assay as a colorectal cancer screening test for the U.S. and European
markets. Epigenomics expects to submit this enhanced Septin9 colorectal cancer
screening test branded Epi proColon® 2.0 to the FDA for regulatory review before
year-end 2011. Under licenses from Epigenomics, Septin9 testing is currently
offered in the U.S.A. by Quest Diagnostics (ColoVantage™) and ARUP Laboratories
(Methylated Septin9 Test) as laboratory-developed tests aiding in the detection
of colorectal cancer. 

Epigenomics legal disclaimers. This communication expressly or implicitly
contains certain forward-looking statements concerning Epigenomics AG and its
business. Such statements involve certain known and unknown risks, uncertainties
and other factors which could cause the actual results, financial condition,
performance or achievements of Epigenomics AG to be materially different from
any future results, performance or achievements expressed or implied by such
forward-looking statements. Epigenomics AG is providing this communication as of
this date and does not undertake to update any forward-looking statements
contained herein as a result of new information, future events or otherwise.
The information contained in this communication does not constitute nor imply an
offer to sell or transfer any product, and no product based on this technology
is currently available for sale by Epigenomics in the United States or Canada.
The analytical and clinical performance characteristics of any Epigenomics
product based on this technology which may be sold at some future time in the
U.S. have not been established.

Further inquiry note:
Dr. Achim Plum
Sen. VP Corporate Development
Epigenomics AG
Tel: +49 30 24345 368

end of announcement                               euro adhoc 

company:     Epigenomics AG
             Kleine Präsidentenstraße 1
             D-10178 Berlin
phone:       +49 30 24345-0
FAX:         +49 30 24345-555
mail:     ir@epigenomics.com
WWW:      www.epigenomics.com
sector:      Biotechnology
ISIN:        DE000A0BVT96, DE000A0XFWF2
indexes:     Prime All Share, Technology All Share
stockmarkets: regulated dealing/prime standard: Frankfurt, free trade: Berlin,
             Hamburg, Stuttgart, Düsseldorf, München 
language:   English

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