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Vasogen Inc.

Vasogen and Grupo Ferrer Form Collaboration to Commercialize Celacade(TM) in the European Union

Toronto, Canada (ots/PRNewswire)

- Vasogen to Host Conference Call Today at 9:00 a.m. (ET)
Vasogen Inc. (NASDAQ:VSGND; TSX:VAS) today announced a
collaboration with  Grupo Ferrer Internacional, S.A. ("Ferrer"), a
leading European  pharmaceutical and medical devices company, to
commercialize Vasogen's Celacade(TM) technology for the treatment of
chronic heart failure in the European Union and in certain Latin
American countries. Under the agreement, Vasogen will receive 45% of
Celacade revenues generated by Ferrer, as set out below, for a period
five years from the date of first commercial sale on a
country-specific basis, and will receive 42% of such revenues
thereafter. Ferrer will be responsible for the costs associated with
the launch and marketing of Celacade in Europe and certain Latin
American countries. Vasogen will also receive milestone payments
based on Ferrer's achievement of first commercial sales of Celacade
on a country-specific  basis, and on reaching pre-specified sales
thresholds. Chronic heart failure is a leading cause of morbidity and
mortality throughout the western world and affects over 6 million
people in Europe alone.
"Chronic heart failure is a major healthcare challenge in the
industrialized world and this agreement represents a significant
economic opportunity for our Celacade technology - a first-in-class
therapeutic entrant," commented Terry Gregg, President, Chief
Executive Officer, and Chairman of Vasogen. "Given Grupo Ferrer's
proven ability to successfully introduce new healthcare technologies
into the large markets of Europe and Latin America, we are extremely
excited about this partnership and look forward to the initial
commercialization of Celacade later this year."
"Having followed the development of Celacade for several years, we
are very enthusiastic about the opportunity for Grupo Ferrer to
market this new immuno-modulatory strategy to the cardiology
community of Europe and Latin America," stated Dr. Carlos de Lecea,
Vice President International & Business Development at Ferrer.
"Celacade offers cardiologists an entirely new way to target the
pathological inflammatory processes of heart failure not addressed by
available therapies, and given the magnitude of the heart failure
problem, we see a large economic opportunity for both Vasogen and
Vasogen will host a conference call and web cast today (Wednesday,
April 18, 2007) at 9:00 a.m. ET, to discuss the collaboration.
Interested parties are invited to participate by connecting 10
minutes prior to the start of the call to one of the following:
    Audio Web Cast:                            
    Direct Dial:                                               416-695-6130
    Toll-free:                                               1-888-789-0150
    A re-broadcast of the conference call may be accessed by:
    Audio Web Cast                             
    Direct Dial:                                               416-695-6034
    Toll-free                                                1-877-605-9320
    Pin Code:                              3259 followed by the number sign
Vasogen/Ferrer Collaboration:
Under the agreement, Ferrer will have the exclusive rights to
market Celacade for the treatment of chronic heart failure and other
cardiovascular conditions in specified countries of Europe, including
Germany, Spain, Portugal, France, and Italy, and certain countries in
Latin America,  Including Mexico, Brazil, Argentina, and Venezuela.
Vasogen has already  Received European Union (EU) regulatory approval
as a medical device under  the CE Mark, which enables marketing of
Celacade for the treatment of chronic heart failure in the 27 member
countries of the European Union. Ferrer has also acquired the right
of first negotiation with respect to the remaining  countries of the
EU. Under the agreement, the commercial launch strategy for  Celacade
in Europe will involve an initial commercialization phase during
which Ferrer will target key opinion leaders in the major markets of
Europe  to ensure support for expanded use of Celacade within the
broader cardiology  community. Ferrer expects to commence the initial
commercialization phase in  the second half of 2007. Following the
completion of the initial  commercialization phase, Vasogen will
receive 45% of Celacade revenues  generated by Ferrer through the
sale of Celacade single-use disposable  cartridges, one of which is
required for the delivery of each Celacade  monthly treatment. After
a period five years from the date of the first  commercial sale on a
country-specific basis, Vasogen's share of the revenues will be 42%.
Also under the terms of the agreement, Ferrer will be  financially
responsible for all costs associated with the launch and  marketing
of Celacade. Vasogen will receive milestone payments based on
Ferrer's achievement of first commercial sales of Celacade on a
country- specific basis, and on reaching pre-specified sales
About Celacade:
Therapy utilizing the Celacade technology targets the inflammation
underlying chronic heart failure and other cardiovascular diseases.
Inflammation is a normal response of the immune system to cellular
injury caused by infection, trauma, or other stimuli. During the
inflammatory process, immune cells release a number of factors,
including cytokines - potent chemical messengers that modulate
inflammation and facilitate the healing process. While this
inflammatory process is usually self-limiting, it can persist, become
chronic, and lead to a number of serious medical conditions.
During a brief outpatient procedure, a small sample of a patient's
blood is drawn into Vasogen's Celacade single-use disposable
cartridge and exposed to controlled oxidative stress utilizing
Vasogen's proprietary Celacade medical device technology. Oxidative
stress is a factor known to initiate apoptosis, a physiologic process
that is inherently anti-inflammatory. The treated blood is then
administered to the same patient intramuscularly. An initial course
of treatment comprising three consecutive outpatient  procedures is
administered over a two-week period, and treatments are  continued
once per month thereafter.
About Grupo Ferrer Internacional, S.A.:
Grupo Ferrer Internacional is a privately held European research
and commercial development based pharmacochemical and medical devices
company headquartered in Barcelona, Spain. Ferrer operates today in
over 60 countries with the overall aim to improve people's health and
quality of life. Based on its policy of continuous expansion
throughout the world, Ferrer has established strong industrial and
commercial operations in Europe and has extensive commercial
experience in Latin America, Africa, and in the Middle and Far East.
Ferrer has licensing, distribution, and marketing agreements with
large multinational pharmaceutical companies, as well as mid-size
firms including AstraZeneca, Astellas, Johnson & Johnson, Merck Sharp
& Dohme, Novartis, Roche, Sanofi-Aventis, Solvay, Cephalon, United
Therapeutics, and The Medicines Co., among others.
In addition to its commercial operations, Grupo Ferrer operates
pharmaceutical research and development facilities in Barcelona,
Spain and Alsdorf, Germany. The research facilities in Barcelona
manage all aspects of drug development from concept through to
clinical development and product registration. The Alsdorf facility
is specialized in new applications of pharmaceutical technology.
Grupo Ferrer also has established research collaborations with a
large number of pharmaceutical companies and universities throughout
the world.
About Vasogen:
Vasogen is a biotechnology company engaged in the research and
Commercial development of therapies designed to target the
destructive  Inflammatory process associated with the development and
progression of  cardiovascular and neurodegenerative disorders. The
Company's lead product,  the Celacade(TM) technology, is designed to
activate the immune response to  apoptosis - an important
physiological process that regulates inflammation.  Celacade is in
late-stage clinical development for the treatment of chronic  heart
failure and has received European regulatory approval under the CE
Mark  for this indication. Vasogen is also developing a new class of
drugs for the  treatment of certain neuro-inflammatory disorders and
is preparing to advance  VP025, the lead drug candidate from this new
class, into phase II evelopment.
Certain statements contained in this press release, the upcoming
conference call and web cast, or elsewhere in our public documents
constitute "forward-looking statements" within the meaning of the
United States Private Securities Litigation Reform Act of 1995 and/or
"forward-looking information" under the Securities Act (Ontario).
These statements may include, without limitation, summary statements
relating to results of the ACCLAIM trial in patients with chronic
heart failure, plans to advance the development of Celacade(TM),
plans to fund our current activities, statements concerning our
partnering activities and health regulatory submissions, strategy,
future operations, future financial position, future revenues,
projected costs, prospects, plans and objectives of management. In
some cases, you can  identify forward-looking statements by
terminology such as "may", "will",  "should", "expects", "plans",
"anticipates", "believes", "estimated",  "predicts", "potential",
"continue", "intends", "could", or the negative of  such terms or
other comparable terminology. We made a number of assumptions  in the
preparation of these forward-looking statements, including
assumptions  about the nature, size and accessibility of the market
for Celacade in the  treatment of chronic heart failure, particularly
in Europe, the regulatory  approval process leading to
commercialization and the availability of capital  on acceptable
terms to pursue the development of Celacade, and the  feasibility of
additional trials. You should not place undue reliance on our
forward-looking statements which are subject to a multitude of risks
and  uncertainties that could cause actual results, future
circumstances or events  to differ materially from those projected in
the forward-looking statements.  These risks include, but are not
limited to, the outcome of further analysis  of the ACCLAIM trial
results, the requirement or election to conduct  additional clinical
trials, delays or setbacks in the regulatory approval  process,
securing and maintaining corporate alliances, the need for
additional capital and the effect of capital market conditions and
other  factors on capital availability, the potential dilutive
effects of any  financing, risks associated with the outcomes of our
preclinical and clinical  research and development programs, the
adequacy, timing and results of our  clinical trials, competition,
market acceptance of our products, the availability of government and
insurance reimbursements for our products, the  strength of
intellectual property, reliance on subcontractors and key  personnel,
losses due to fluctuations in the U.S.-Canadian exchange rate, and
other risks detailed from time to time in our public disclosure
documents or  other filings with the Canadian and U.S. securities
commissions or other  securities regulatory bodies. Additional risks
and uncertainties relating to  our Company and our business can be
found in the "Risk Factors" section of  our Annual Information Form
and Form 20-F for the year ended November 30,  2006, as well as in
our later public filings. The forward-looking statements  are made as
of the date hereof, and we disclaim any intention and have no
obligation or responsibility, except as required by law, to update or
revise  any forward-looking statements, whether as a result of new
information,  future events or otherwise. Unless otherwise indicated,
numerical values  indicating the statistical significance
("p-values") of results included in  this document are based on
analyses that do not account for endpoint  multiplicity.


For further information: Glenn Neumann, Investor Relations, 2505
Meadowvale Blvd., Mississauga, ON, Canada, L5N 5S2, tel:
+1-905-817-2004, fax: +1-905-569-9231,