Roche Pharmaceuticals

New Data Show That Herceptin, Xeloda and Avastin Help Patients With Early and Advanced Breast Cancer Live Longer or Remain Disease Free for Longer

    Basel, Switzerland (ots/PRNewswire) -

    - Roche Medicines Offer Improved Ways of Fighting the Leading Cause of Cancer Death in Women

    New data being presented at the CTRC-AACR San Antonio Breast Cancer Symposium (SABCS) show that Herceptin (trastuzumab), Avastin (bevacizumab) and oral Xeloda (capecitabine) continue to offer new and better treatment options for breast cancer patients allowing women to live longer or remain disease free for longer if the medicines are given before and after surgery as well as in advanced stages of disease.

@@start.t1@@      Key data being presented include:
      - Herceptin before surgery: Results from the NOAH (NeOAdjuvant Herceptin)
         phase III study showed that women with locally advanced HER2-positive
         breast cancer who started a combination of Herceptin and standard
         chemotherapy prior to surgery had a significantly greater chance of
         living free of their disease (event-free survival) three years after
         initiation of treatment as compared to women who were receiving pre-
         operative chemotherapy alone.
      - Xeloda in early breast cancer: Early data from an independent study in
         Finland and Sweden indicate that the chemotherapy pill Xeloda, which is
         already proven in advanced breast cancer, may also reduce the
         recurrence of early breast cancer and help women live longer. This is
         one of 20 Xeloda abstracts that have been accepted for presentation
         during SABCS.
      - Avastin in advanced breast cancer: First efficacy results from the
         largest ever safety study of Avastin in a real-life setting, which
         involved more than 2,000 patients with locally recurrent or metastatic
         breast cancer, confirm that Avastin can be used with a broad range of
         chemotherapy treatments giving patients a median of almost 10 months
         without their disease getting worse. The results, which are one of 24
         separate Avastin data presentations during SABCS, confirm that Avastin
         based therapy is essential for improving the lives of women with
         advanced breast cancer.@@end@@

    "Researching new cancer treatments is a complex step by step process. Each success helps lay the foundation for the next step forward," said William M. Burns, CEO Division Roche Pharmaceuticals. "These results show that we are making significant progress towards giving doctors and their breast cancer patients better and more effective treatment options to fight this devastating disease at all stages," he added.

@@start.t2@@      Presentation of Data
      Gianni L et al  Neoadjuvant trastuzumab in patients with    Friday 12th
                                HER2-positive locally advanced breast         December
                                cancer: primary efficacy analysis of the    09:30 hrs
                                NOAH trial                                                    General
                                                                                                    Session 3
                                                                                                    (Hall D)
      Joensuu H et      Significant improvement in                          Sunday 14th,
      al. for The        recurrence-free survival (RFS)                    December
      Finnish Breast  when capecitabine (X) is                              11:45 hrs
      Cancer Group      integrated into docetaxel (T)
                                5-FU + epirubicin +                                      General
                                cyclophosphamide (CEF) adjuvant                  Session 7
                                therapy for high-risk early
                                breast cancer (BC): interim
                                analysis of the FinXX-trial.
      Smith IE et al  Primary analysis of study MO19391, an         Saturday
                                open-label safety study of bevacizumab        13th
                                plus taxane-based therapy as 1st-line         December
                                treatment of patients with locally              07:00 hrs
                                recurrent or metastatic breast cancer.
                                                                                                    Session 4@@end@@

    The above mentioned studies and data represent the latest results of clinical research for each treatment and are not necessarily part of the indicated licence in each country. For detailed label information, visit the website of your health authority or the EMEA website

    Note to Editors

    Breast cancer is the most common cancer among women worldwide.(i) Each year more than one million new cases of breast cancer are diagnosed worldwide, and nearly 400,000 people will die of the disease annually.(ii) In HER2-positive breast cancer, increased quantities of the HER2 protein are present on the surface of the tumour cells. This is known as 'HER2-positivity'. High levels of HER2 are present in a particularly aggressive form of the disease which responds poorly to chemotherapy. Research shows that HER2-positivity affects approximately 20-30 percent of women with breast cancer.(iii)

    About Roche

    Headquartered in Basel, Switzerland, Roche is one of the world's leading research-focused healthcare groups in the fields of pharmaceuticals and diagnostics. As the world's biggest biotech company and an innovator of products and services for the early detection, prevention, diagnosis and treatment of diseases, the Group contributes on a broad range of fronts to improving people's health and quality of life. Roche is the world leader in in-vitro diagnostics and drugs for cancer and transplantation, and is a market leader in virology. It is also active in other major therapeutic areas such as autoimmune diseases, inflammatory and metabolic disorders and diseases of the central nervous system. In 2007 sales by the Pharmaceuticals Division totalled 36.8 billion Swiss francs, and the Diagnostics Division posted sales of 9.3 billion francs. Roche has R&D agreements and strategic alliances with numerous partners, including majority ownership interests in Genentech and Chugai, and invested over 8 billion Swiss francs in R&D in 2007. Worldwide, the Group employs about 80,000 people. Additional information is available on the Internet at

    All trademarks used or mentioned in this release are legally protected.

@@start.t3@@      References
      (i) World Health Organization,
      (ii) Ferlay J, et al., GLOBOCAN 2002. Cancer Incidence, Mortality and
              Prevalence Worldwide. IARC CancerBase No.5, Version 2.0. IARCPress,
              Lyon, 2004. 2004.
      (iii) Harries M, Smith I. The development and clinical use of trastuzumab
                (Herceptin). Endocr Relat Cancer 9: 75-85, 2002.@@end@@

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