EvaluatePharma Ltd

Pfizer Reigns Supreme After Patent Cliff as Humira Kicks Avastin off Top Spot

London, May 3, 2010 (ots/PRNewswire) - The rheumatoid arthritis treatment Humira will replace Lipitor as the world's biggest-selling drug in 2016, but a familiar name, Pfizer, will still be the biggest seller of medicines after the patent cliff according to the World Preview 2016 report published today by EvaluatePharma, the premier provider of pharma and biotech analysis. The cancer treatment Avastin had been widely expected to emerge as the biggest blockbuster drug following patent expiry next year for Lipitor, a cholesterol-lowering drug. However, Avastin has experienced some clinical setbacks this year and as a result Humira is now forecast to be the top drug with sales of $10.1bn in 2016, according to the EvaluatePharma report. Meanwhile, Pfizer, through a strategy of mergers and acquisitions including last year's $68bn mega-merger with Wyeth, will cling to the top spot in prescription sales, although Merck & Co, thanks to its $41bn merger with Schering-Plough last year, will be close behind. WW Prescription (Rx) WW Annual Market Market Pharmaceutical Sales Sales ($bn) Share Rank Rank 2009 2016 Annual 2009 2016 2009 2016 Growth (09 - 16) 1 Pfizer * 55.3 47.1 -2% 8.6% 6.0% 1 1 2 Merck & Co * 41.6 46.3 +2% 6.5% 5.9% 2 2 3 Novartis 37.3 46.0 +3% 5.8% 5.9% 4 3 4 Roche 36.0 43.9 +3% 5.6% 5.6% 6 4 5 Sanofi-Aventis 38.3 38.9 +0% 6.0% 5.0% 3 5 6 GlaxoSmithKline 36.3 38.7 +1% 5.6% 4.9% 5 6 7 Abbott Laboratories 16.5 26.1 +7% 2.6% 3.3% 10 7 8 Johnson & Johnson 21.3 24.8 +2% 3.3% 3.2% 8 8 9 AstraZeneca 31.6 22.1 -5% 4.9% 2.8% 7 9 10 Teva Pharmaceutical 12.6 20.8 +7% 2.0% 2.7% 15 10 Industries * Proforma data in 2009 (Pfizer+Wyeth / Merck+Schering-Plough) A surprise in the top pharma sales list is the entrance of Teva, the Israeli generics company which will become an increasingly large pharma player as the industry's patent cliff looms. Over the next seven years Teva will push into the top ten ahead of some more traditional big pharma groups like Bristol-Myers Squibb, Eli Lilly and Amgen. In terms of therapy areas biotech products targeting cancer and rheumatic disorders look set to dominate the scene, accounting for six of the top 10 in 2016. Only Glaxo's respiratory medicine Advair, which is proving incredibly resilient to generic challengers, and AstraZeneca's cholesterol fighter Crestor, will be carrying the flame for conventional, small molecules drugs in 2016. Top Ten Selling Products in 2016 WW annual sales ($bn) Rank Product Company(s) Drug Target Technology 2009 2016Annual Growth (09-16) 1 Humira Abbott Laboratories /Eisai Arthritis Biotech 5.6 10.1 9% (monoclonal antibody) 2 Avastin Roche Cancer Biotech 5.7 8.9 6% (monoclonal antibody) 3 Enbrel Amgen/Pfi Arthritis Biotech 6.5 7.3 2% zer/Takeda (recombinant product) 4 Rituxan Roche/Biogen Cancer Biotech 5.6 6.8 3% Idec (monoclonal antibody) 5 Crestor AstraZeneca/ Cholesterol Conventional 4.8 6.3 4% Shionogi/Chiesi -lowering (small molecule) 6 Herceptin Roche Cancer Biotech 4.9 6.2 3% (monoclonal antibody) 7 Remicade Johnson & Arthritis Biotech 5.9 5.7 0% Johnson/Merck & (monoclonal Co/Mitsubishi antibody) Tanabe 8 Lantus Sanofi-Aventis Insulin Biotech 4.3 5.3 3% for diabetes (recombinant product) 9 Advair/ GlaxoSmithKline Asthma Conventional 8.0 5.2 -6% Seretide /Almirall/Others (small molecule) 10 Prolia Amgen/Daiichi Osteoporosis Biotech 0 5.2 - Sankyo/GlaxoSm (monoclonal ithKline antibody) Commenting on the launch of the report, Jonathan de Pass, EvaluatePharma CEO, said: "The next seven years will see huge growth in sales of complex biologics, driven in part by the premium price they can command and the industry's productivity in getting these compounds to market. We will also see generics players such as Teva achieving impressive growth due to a continued sales erosion of blockbuster products coming off patent." "Our World Preview report gives a snapshot of the industry in 2016. This is the first time this data has been available and will provide a valuable insight into the new competitive pharma landscape beyond the patent cliff." EvaluatePharma launched the report today at BIO 2010 in Chicago, Illinois, United States. More information on EvaluatePharma's World Preview 2016, which assess forecasted trends in prescription drug sales, R&D spend, therapy area growth and the performance of marketed and pipeline products, can be found at EvaluatePharma's stand at BIO 2010 (2436) or via EvaluatePharma's website http://www.evaluatepharma.com Notes to editors About EvaluatePharma (R) - http://www.evaluatepharma.com Set up in 1996 by former top pharma analyst Dr. Jonathan de Pass, EvaluatePharma(R) is the premier source for pharma and biotech analysis. EvaluatePharma was the first company to supply reliable consensus forecasts of global drug sales and now provides standardised worldwide financial and forecast models with consensus product forecasts to 2016, data on R&D pipelines, licensing deals, patent risk and M&A deals, along with analytical tools that include, Merge Company and Peer Group Analyzer and over 3000 global product NPVs (Net Present Value) linked to share price. In 2007 EvaluatePharma(R)Alpha launched offering a valuation service designed to quantify market events and the impact on product, portfolio and company valuation - NPV Analyzer, Calendar of Events and the daily news service EP Vantage. Last year, Evaluate Ltd, the parent company of EvaluatePharma, was awarded the Queen's Award for Enterprise: International Trade. ots Originaltext: EvaluatePharma Ltd Im Internet recherchierbar: http://www.presseportal.ch Contact: CONTACT: For all media enquiries please contact: At BIO 2010 and USenquiries, College Hill Life Sciences, Erik Clausen, Mob:+1-781-608-7091,Tel: +1-415-230-5385, Erik.clausen@collegehill.com, UK and Europeanenquiries, Katja Toon and Justine Lamond, Tel:+44-20-7688-7857,Justine.lamond@collegehill.com

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