Boehringer Ingelheim Animal Health

Landmark Research Heralds New Era in Dog Heart Treatment and Longer Life for Dogs

Ingelheim, Germany (ots/PRNewswire) - - For Non-US Healthcare Media - Global QUEST Study Reveals Dogs With Congestive Heart Failure Have Significantly Improved Survival Outcomes With Vetmedin(R) (pimobendan) Veterinarians and dog owners are today welcoming new research that delivers the promise of an extended happy life together for millions of dog owners and their pets. The three-year study demonstrates that dogs suffering from the most common type of heart failure live on average 91% (267 days vs. 140 days) longer when treated with the product Vetmedin(R) (pimobendan) compared with another common treatment option(1). To view the Multimedia News Release, go to: http://www.prnewswire.com/mnr/boehringeringelheim/34774/ Results from the QUEST (Quality of Life and Extension of Survival Time) study, published in the current issue of the Journal of Veterinary Internal Medicine, mark a significant milestone in canine cardiac health. Experts report that 25% of all small to medium-sized dogs over the age of seven are likely to suffer from heart disease at some point in their life(2), and 75% of those cases are caused by myxomatous mitral valve disease (MMVD)(3), sometimes known as "valvular insufficiency" or "endocardiosis". Adrian Boswood from the Royal Veterinary College, London, a Veterinary Cardiology Specialist and a lead-investigator on the study, explains that the independent QUEST trial set out to explore the impact on survival of Vetmedin(R) versus another current treatment, benazepril hydrochloride, an angiotensin-converting enzyme (ACE) inhibitor. "With QUEST demonstrating that dogs treated with Vetmedin(R) live on average nearly twice as long as those on benazepril(1), it is now time for us as veterinary cardiologists and practising veterinarians to look again at how we are treating our patients suffering from this serious condition." Dr. Michael O'Grady from the Ontario Veterinary College, University of Guelph, a fellow lead-investigator added, "The QUEST study provides compelling evidence that dogs with the most common form of heart failure should be receiving Vetmedin(R) as an essential part of their treatment regimen." QUEST is the largest international study ever conducted looking at treatment for congestive heart failure (CHF) caused by MMVD, with 260 dogs studied in 11 countries, across three continents, over a period of three years. The study was conducted by a team of 32 independent veterinary cardiologists from Australia, Canada, France, Germany and the United Kingdom among other countries. CHF caused by MMVD most commonly affects older, small breed dogs, including Cavalier King Charles Spaniels, Poodles, Chihuahuas and Dachshunds.(3) Symptoms of this form of heart failure that dog owners should look for include coughing, reduced tolerance for exercise, anxiety and restlessness during the night, and laboured breathing.(3) If these symptoms are present, it is important that dog owners take their pets to their veterinarians for assessment and treatment. "Dog owners should be encouraged by the results of the QUEST study, as it demonstrates an important treatment option for lengthening a dog's life when it has this common, debilitating and life-threatening heart condition," said Jens Häggström, Professor of Veterinary Internal Medicine, University of Uppsala and the other lead-investigator on the trial. Owners now have new information regarding the best chance for enjoying the maximum time possible with their dogs suffering from the most common cause of heart failure. "With our dogs being so important to our families, we owners should do all we can to make sure our pets are receiving the most effective treatment", said Sally Copland, owner of Fern, an eight-year-old King Charles Spaniel being treated with Vetmedin(R). "None of us want our pets' lives unnecessarily cut short," she added. The full QUEST study results, providing hard evidence about the importance of using Vetmedin, appear in the September/October 2008 issue of the Journal of Veterinary Internal Medicine. For more information on the QUEST study and on CHF caused by MMVD, please visit http://www.questtrial.com Boehringer Ingelheim Boehringer Ingelheim Animal Health and Boehringer Ingelheim Vetmedica belong to the Boehringer Ingelheim group of companies. The Boehringer Ingelheim group is one of the world's 20 leading pharmaceutical companies. Headquartered in Ingelheim, Germany, it operates globally with 135 affiliates in 47 countries and 39,800 employees. Since it was founded in 1885, the family-owned company has been committed to researching, developing, manufacturing and marketing novel products of high therapeutic value for human and veterinary medicine. In 2007, Boehringer Ingelheim posted net sales of almost 11 billion euro while spending one fifth of net sales in its largest business segment, Prescription Medicines, on research and development. The animal health business is conducted in more than 20 countries including USA, Canada, France, Germany, UK, Italy, Spain, Mexico, the Nordic countries Japan and China. Since 1955, Boehringer Ingelheim Animal Health is contributing to an adequate supply of safe, nutritious food and is promoting the emotional and physical benefits arising from the human-animal bond. For more information, please visit http://www.boehringer-ingelheim.com --------------------------------- References (1) Häggström J, Boswood A, O'Grady M et al. Effect of Pimobendan or Benazepril Hydrochloride on Survival Times in Dogs with Congestive Heart Failure Caused by Naturally Occurring Myxomatous Mitral Valve Disease: The QUEST Study. J Vet Intern Med. 2008;22(5). (2) Evans T, Johnson C, Wernham J. Cardiovascular Insight: A global study of category prospects. Wood Mackenzie. July 2007. (3) Häggström J, Kvart C and Pedersen H. "Acquired valvular heart disease" in Ettinger SJ, Feldman EC (Eds). Textbook of veterinary internal medicine: diseases of the dog and cat. 2005 (6th edition). ots Originaltext: Boehringer Ingelheim Animal Health Im Internet recherchierbar: http://www.presseportal.ch Contact: Contacts: Philip Sheldon, Red Door Communications, Phone: +44-208-392-8093, Email: psheldon@rdcomms.com; Rikki Jones, Red Door Communications, Phone: +44-208-392-8062, Email: rjones@rdcomms.com; Julia Meyer-Kleinmann, Head Science & Technology Communications, Boehringer Ingelheim GmbH, 55216 Ingelheim/Germany, Phone: +49-6132-77-8271, Fax: +49-6132-77-7077, E-mail: press@boehringeringelheim.com. Veterinary cardiology experts in the following countries are available for comment. For country-specific information please contact: Australia / New Zealand: Angela Hinchley, Spinifex Communications, +61-(02)9954-4051, angela.hinchley@spinifexcommunications.com.au; Canada: Cristiane Doherty, Delta Media Inc., +1-613-233-9191, Cristiane@DeltaMedia.ca; France: Dominique Kerforn, i&e Consultants, +33-1-56-03-12-75, dkerforn@i-e.fr; Germany: Veterinary press: Deiter Wense, Pressebüro Vennebusch, +49-53-61-88-83-00, vdwense@inpunctodesign.de; Consumer press: Petra von der Lage, MasterMedia, +49-40-50-71-13-44, vonderlage@mastermedia.de; UK: Danny Stepto, Red Door Communications, +44-208-392-8040, dstepto@rdcomms.com; USA: Illinois Blasdel, Blasdel Cleaver Schwalbe Communications, LLC, Illinois@bcsthinktank.com, +1-816-474-3166

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