SYGNIS AG

EANS-Adhoc: SYGNIS Pharma AG announces strategic restructuring

-------------------------------------------------------------------------------- ad-hoc disclosure pursuant to section 15 of the WpHG transmitted by euro adhoc with the aim of a Europe-wide distribution. The issuer is solely responsible for the content of this announcement. -------------------------------------------------------------------------------- Company Information 29.10.2010 Ad-hoc SYGNIS Pharma AG announces strategic restructuring Heidelberg, 29 October 2010 - SYGNIS Pharma AG (Frankfurt: LIO; ISIN DE0005043509; Prime Standard) announced today a comprehensive, strategic restructure of the company, which will include significant personnel and cost reductions. The process has been approved by the Supervisory Board and will be executed immediately. The purpose of the restructuring is to reduce SYGNIS´ long-term cost-structure to maintain a strategic focus on the Company´s current projects, including the clinical development of its lead compound AX200 for the treatment of acute stroke, which is currently in a phase II efficacy trial (AXIS 2). The total number of employees will be reduced from 51 to 32 (an equivalent of 21 Full Time Employees). The core pre-clinical and clinical development teams will remain in place to complete ongoing AX200 development work as well as research on the KIBRA pathway. Relating to the restructuring, the Company expects a one-time total expense of up to EUR 0.5 million, which will occur in full in the fiscal year 2010/11. Additional non-cash related expenses of up to EUR 2.5 million could occur with regard to an impairment of intangible assets. With the reduced cost-base and the current liquidity it is expected that SYGNIS will have sufficient funds to support the completion of the ongoing phase II efficacy study for AX200. In addition, the Company has access to an equity-line by Yorkville Advisors, which will further extend SYGNIS´ financial runway. The Board believes the new structure of the Company should position it more favourably for potential future strategic transactions. For further information please contact: SYGNIS Pharma AG: |Dr. Franz-Werner Haas | |Vice President Operations/ General | |Counsel | |+49 (0) 6221 454 812 | |franz-werner.haas@sygnis.de | end of announcement euro adhoc -------------------------------------------------------------------------------- ots Originaltext: SYGNIS Pharma AG Im Internet recherchierbar: http://www.presseportal.ch Further inquiry note: Dr. Franz-Werner Haas Vice President Operations/ General Counsel +49 (0) 6221 454 812 franz-werner.haas@sygnis.de Branche: Biotechnology ISIN: DE0005043509 WKN: 504350 Index: CDAX, Prime All Share Börsen: Frankfurt / regulated dealing/prime standard Berlin / free trade Hamburg / free trade Stuttgart / free trade Düsseldorf / free trade Hannover / free trade München / free trade

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