SYGNIS AG

euro adhoc: Disclosure announcement after § 15 WpHG
LION Bioscience AG
Board of Directors (Appointments and Changes)
Supervisory Board of LION bioscience AG Resigns

--------------------------------------------------------------------- Disclosure announcement transmitted by euro adhoc. The issuer is responsible for the content of this announcement. --------------------------------------------------------------------- LION bioscience AG, Cambridge, MA, USA, Heidelberg, Germany, October 14, 2004 – LION bioscience (Nasdaq: LEON) today announced that the Supervisory Board of LION bioscience AG, Jürgen Dormann, Prof. Klaus Pohle and Richard Roy stepped down effective immediately after yesterdays Supervisory Board meeting. Due to its NASDAQ listing the company could not extent its Directors & Officers insurance at economically feasible terms. The local trade court in Heidelberg will appoint the new Supervisory Board. Dr. Friedrich von Bohlen, a major shareholder of the company, has indicated his support for this process. end of announcement euro adhoc 14.10.2004 09:27:13 --------------------------------------------------------------------- Further inquiry note: Günter Dielmann, Tel.: +49 6221 4038-249, guenter.dielmann@lionbioscience.com Julia Fritz, Tel.: +49 6221 4038-158, julia.fritz@lionbioscience.com Tracy Coffey, Tel.: +1 857 919 9975, tracy.coffey@lionbioscience.com Branche: Pharmaceuticals ISIN: DE0005043509 WKN: 504350 Index: Nemax 50, Prime Standard Börsen: Frankfurter Wertpapierbörse / regulated dealing New York / regulated dealing Berliner Wertpapierbörse / free trade Hamburger Wertpapierbörse / free trade Baden-Württembergische Wertpapierbörse / free trade Börse Düsseldorf / free trade Niedersächsische Börse zu Hannover / free trade Bayerische Börse / free trade Bremer Wertpapierbörse (BWB) / free trade

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