Eisai Europe Limited

Eisai Presents new Research for Investigational Compound Lenvatinib at the European Society for Medical Oncology

Vienna, Austria (ots/PRNewswire) - INTENDED FOR EUROPEAN MEDIA ONLY

Results from a Phase I/II trial of the investigational compound lenvatinib (E7080), a multi-targeted, kinase inhibitor, in people with advanced hepatocellular cancer have been presented at the ESMO 2012 Congress (European Society for Medical Oncology) taking place on Friday 28 September - Tuesday 2 October.[1] Two other studies were presented, reporting the results of lenvatinib in the treatment of recurrent glioblastoma (the most common type of brain cancer which is almost universally fatal) and lenvatinib in combination with everolimus in metastatic renal cell carcinoma.[2],[3]

The following Eisai posters were presented at this year's ESMO 2012 Congress:

                               A Phase 2 Trial of the Multi-targeted
                               Kinase Inhibitor Lenvatinib (E7080) in
        Lenvatinib (E7080)     Patients With Recurrent Glioblastoma
                               (GBM) and Disease Progression Following
        Abstract No: 417PD     Prior Bevacizumab Treatment
        Poster Session         D.A. Reardon, E. Pan, J. Fan, J. Mink,
                               D. Barboriak, J.J. Vredenburgh, A.
        Saturday 29th          Desjardins, K. Peters, J.P. O'Brien, P.
        September 13:00-14:00  Wen
                               A Phase Ib Clinical Trial of the
        Lenvatinib (E7080)     Multi-targeted Kinase Inhibitor
                               Lenvatinib (E7080) in Combination With
        Abstract No: 814P      Everolimus for Treatment of Metastatic
                               Renal Cell Carcinoma (RCC)
        Poster Session         A.M. Molina, T.E. Hutson, J.M.G.
        Saturday 29th          Larkin, A. Gold, C. Andresen, K. Wood,
        September 13:00-14:00  R. Motzer, M.D. Michaelson
        Lenvatinib (E7080)     Phase I/II Trial of Lenvatinib (E7080),
                               a Multi-targeted Tyrosine Kinase
        Abstract No: 737P      Inhibitor, in Patients with Advanced
                               Hepatocellular Carcinoma (HCC)
        Poster Session         K. Ikeda, H. Kumada, M. Kudo, S.
        Sunday 30th September  Kawazoe, Y. Osaki, M. Ikeda, T.Okusaka,
        13:00-14:00            T. Suzuki, J P O'Brien, K. Okita 

"Presentation of these data at ESMO demonstrates continued progress in the development of lenvatinib. Eisai's human health care mission is to help address unmet medical needs and provide healthcare benefits to patients and their families," says Dr Jim O'Brien, Eisai's Lenvatinib International Team Lead. "Our commitment to the development of lenvatinib underscores our commitment to this important mission."

Notes to Editors

Lenvatinib (E7080)

Lenvatinib is an orally active inhibitor of multiple receptor tyrosine kinases (RTKs), including KDR (VEGFR-2), Flt-1 (VEGFR-1), FGFR1, PDGFR-beta and c-kit involved in angiogenesis and tumour proliferation.[4],[5] It is currently being investigated as a treatment for thyroid, hepatocellular, endometrial and other solid tumour types.

Eisai in Oncology

Eisai is dedicated to discovering, developing and producing innovative oncology therapies that can make a difference and impact the lives of patients and their families. This passion for people is part of Eisai's human health care (hhc) mission, which strives for better understanding of the needs of patients and their families to increase the benefits health care provides. Our commitment to meaningful progress in oncology research, built on scientific expertise, is supported by a global capability to conduct discovery and preclinical research, and develop small molecules, therapeutic vaccines, and biologic and supportive care agents for cancer across multiple indications.

About Eisai:

Eisai recently expanded their UK Hatfield commercial, research and manufacturing facility which now supports the company's growing EMEA business.

Eisai concentrates its R&D activities in three key areas:

        - Neuroscience, including: Alzheimer's disease, epilepsy, pain and weight
          loss
        - Oncology including: anticancer therapies; tumour regression, tumour
          suppression, antibodies, etc
        - Vascular/Immunological reaction including: thrombocytopenia, rheumatoid
          arthritis, psoriasis, inflammatory bowel disease 

With operations in the U.S., Asia, Europe and its domestic home market of Japan, Eisai employs more than 11,000 people worldwide. In Europe, Eisai undertakes sales and marketing operations in over 20 markets, including the United Kingdom, France, Germany, Italy, Spain, Switzerland, Sweden, Ireland, Austria, Denmark, Finland, Norway, Portugal, Iceland, Czech Republic, Slovakia, the Netherlands, Belgium, Luxembourg, the Middle East and Russia.

For further information please visit our web site http://www.eisai.com.

References:

1. Ikeda, K. Kumada, H. Kudo, et al. Phase I/II trial of Lenvatinib (E7080), a multi-targeted tyrosine kinase inhibitor, in patients with advanced hepatocellular carcinoma. Poster presented at the ESMO Congress, Vienna, 2012

2. Reardon, D.A. Pan, E. Fan, et al. A Phase 2 Trial of the multi-targeted kinase inhibitor lenvatinib (E7080) in patients with recurrent glioblastoma and disease progression following prior bevacizumab treatment. Poster presented at the ESMO Congress, Vienna, 2012

3. Molina, AM. Hutson, TE. Larkin, et al. A Phase Ib clinical trial of the multi-targeted kinase inhibitor lenvatinib (E7080) in combination with everolimus for the treatment of metastatic renal cell carcinoma. Poster presented at the ESMO Congress, Vienna, 2012

4. Matsui J, Funahashi Y, Uenaka T et al. Multi-kinase inhibitor E7080 suppresses lymph node and lung metastases of human mammary breast tumour MDA-MB-231 via inhibition of vascular endothelial growth factor-receptor (VEGF-R) 2 and VEGF-R3 kinase. Clin Cancer Res 2008; 14: 5459-65.

5. Matsui J, Yamamoto Y, Funahashi Y, et al. E7080, a novel inhibitor that targets multiple kinases, has potent anti-tumour activities against stem cell factor producing human small cell lung cancer H146, based on angiogenesis inhibition. Int J Cancer 2008; 122: 664-71.

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Date of preparation: September 2012

Job code: Lenvatinib-UK0006

Contact:

Media Enquiries: Eisai Europe Ltd, Charlotte Andrews / Cressida
Robson, +44(0)7947-23-1513, +44(0)790-831-4155,
charlotte_andrews@eisai.net / cressida_robson@eisai.net ; Tonic
Life
Communications: Holly Matthews/ April Kenneally, +44(0)207-798-9992
/
+44(0)773-881-6935, +44(0)207-798-9263 / +44(0)788-561-4274,
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