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IsoTis OrthoBiologics

IsoTis Expects Delisting From SWX, Euronext, and TSX in July 2007

Irvine, California (ots/PRNewswire)

IsoTis, Inc. (NASDAQ: ISOT),
the orthobiologics company, today announced that it is at the final
stage of concluding the Exchange Offer it launched for all of the
outstanding shares of ISOTIS SA on December 15, 2006. After this last
step of the Exchange Offer, ISOTIS SA will no longer be listed on SWX
Swiss Exchange, Euronext Amsterdam and the Toronto Stock Exchange.
On February 7, 2007, at the end of the first phase of the Exchange
Offer, 64,180,460 shares in ISOTIS SA had been tendered, representing
approximately 90.5% of the issued and outstanding share capital of
the ISOTIS SA. As announced in the prospectuses issued in connection
with the Exchange Offer and in the communications by the company
during the Exchange Offer, IsoTis, Inc., is preparing to obtain the
approximately 9.5% still outstanding ISOTIS SA shares through a
squeeze-out merger under Swiss law. The squeeze-out merger will occur
following a vote of the shareholders at an Extraordinary General
Meeting (EGM). The required vote to effect the squeeze-out merger is
90% of the outstanding shares. Because IsoTis, Inc. owns in excess of
90% of the outstanding shares of ISOTIS SA and intends to vote those
shares in favor of the squeeze-out merger at the EGM, the company
expects that the squeeze-out merger will be approved. Once the
squeeze-out merger is approved, ISOTIS SA will merge with IsoTis
International SA, a newly formed subsidiary of IsoTis, Inc. In
connection with the merger, shareholders of ISOTIS SA will receive,
in exchange for their ISOTIS SA shares, shares of common stock of the
company under the same conditions as shareholders who participated in
the Exchange Offer, namely one company share for every 10 ISOTIS SA
shares. The company shares issued in the squeeze-out merger will be
listed on the Nasdaq Global Market.
The company will request that as soon as the EGM of the
shareholders of ISOTIS SA has passed the required motion, and the
merger becomes effective, the ISOTIS SA shares will be delisted from
SWX Swiss Exchange, Euronext Amsterdam, and from the Toronto Stock
Exchange. The EGM will be held on July 23 from 9 am until
approximately 9:30 am in Lausanne, Switzerland.
Projected Timeline
June 18 Mailing of Notice of Extraordinary General Meeting of
ISOTIS SA to registered shareholders
July 23 Extraordinary General Meeting of ISOTIS SA, followed by
delisting of ISOTIS SA shares from SWX Swiss Exchange, Euronext
Amsterdam, and the Toronto Stock Exchange
Approximately July 27 Settlement of share exchange
About IsoTis, Inc.
IsoTis is a leading orthobiologics company that develops,
manufactures and markets proprietary products for the treatment of
musculoskeletal diseases and disorders. IsoTis' current
orthobiologics products are bone graft substitutes that promote the
regeneration of bone and are used to repair natural, trauma-related
and surgically-created defects common in orthopedic procedures,
including spinal fusions. IsoTis' current commercial business is
highlighted by its Accell line of products, which the company
believes represents the next generation in bone graft substitution.
Certain statements in this press release are "forward-looking
statements" within the meaning of Section 21E of the Securities
Exchange Act of 1934, as amended, including those that refer to
management's plans and expectations for future operations, prospects
and financial condition. Words such as "strategy," "expects,"
"plans," "anticipates," "believes," "will," "continues," "estimates,"
"intends," "projects," "goals," "targets" and other words of similar
meaning are intended to identify such forward-looking statements. One
can also identify them by the fact that they do not relate strictly
to historical or current facts. Such statements are based on the
current expectations of the management of IsoTis only. Undue reliance
should not be placed on these statements because, by their nature,
they are subject to known and unknown risks and can be affected by
factors that are beyond the control of IsoTis. Actual results could
differ materially from current expectations due to a number of
factors and uncertainties affecting IsoTis' business, including, but
not limited to, a competitive sales and marketing environment, the
timely commencement and success of IsoTis' clinical trials and
research endeavors, delays in receiving U.S. Food and Drug
Administration or other regulatory approvals (i.e.. EMEA, CE),
including the risk that the Company is unable to obtain 510(k)
clearance for its Accell products, that the FDA requires the Company
to produce additional clinical data to support approval or clearance
of its products, that the FDA imposes compliance measures against the
Company for the marketing of its Accell products, including imposing
fines and injunctions or causing the Company to recall its Accell
products, market acceptance of IsoTis' products, effectiveness of
IsoTis' distribution channels, development of competing therapies
and/or technologies, the terms of any future strategic alliances, the
need for additional capital, the inability to obtain, or meet,
conditions imposed for required governmental and regulatory approvals
and consents. IsoTis expressly disclaims any intent or obligation to
update these forward-looking statements except as required by law.
For a more detailed description of the risk factors and uncertainties
affecting IsoTis, refer to the Annual Report on Form 20-F for the
fiscal year ended December 31, 2005 and Quarterly Report on Form 10-Q
for the quarter ended March 31, 2007 of IsoTis SA, the predecessor of
the Company, filed with the SEC, to IsoTis SA's reports filed from
time to time with the Swiss Stock Exchange (SWX), Euronext Amsterdam
N.V., SEDAR at www.sedar.com and the Toronto Stock Exchange (TSX),
and to the reports filed from time to time by the Company with the
SEC, including its Quarterly Report on Form 10-Q for the quarterly
period ended March 31, 2007.
The Exchange Offer is being made for the shares of IsoTis SA, a
Swiss company, that are listed on the SWX Swiss Exchange, on Euronext
Amsterdam N.V. and the Toronto Stock Exchange. The Exchange Offer is
subject to disclosure requirements of Switzerland, the Netherlands
and Canada, which requirements may be different from those of the
United States. U.S. shareholders should be aware that, to the extent
permissible, IsoTis, Inc. may purchase IsoTis Swiss Shares otherwise
than under the Exchange Offer, such as in open market or privately
negotiated purchases.

Contact:

For information contact: Rob Morocco, CFO, +1-949-855-7155,
robert.morocco@isotis.com; Hans Herklots, Director IR,
+1-949-855-7195 or +41-21-620-6011, hans.herklots@isotis.com

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